Intravenous Administration of Nicotinamide Adenine Dinucleotide Significantly Reduces Self Report Craving Ratings Associated With Opiate and Alcohol Withdrawal*
Treatment of substance abuse disorders continues to challenge clinicians and “cravings” for the abused substance are often impediments to sobriety. NicotinamideAdenine Dinucleotide (NAD+) has been used in the past with claims of having anti-craving properties. Previous data from this clinic using a similar formulation of NAD+ support the use of NAD+ as a valid treatment for drug cravings. This pilot study retrospectively examined the anti-craving properties of NAD+ in a group of 60 patients. Additionally, patients were assessed on severity of cravings and relapse episodes at 12-20 months post treatment.
The patients were adult males and females with addictions to primarily opiates or alcohol (N=60). Six patients were omitted due to incomplete data. The treatment, Brain Restoration Plus (BR+)TMcomprised of IV infusions of NAD+ as well as vitamins, oral amino acids, NAC and variable PRN medications for an average of 10 consecutive days ranging from 5 to 10 hours daily at a dose range of 500mg-1500mg each day. Self-reported craving ratings (0-10 Scale) were collected on Day 1 (before starting treatment), Day 5, and on Day 10 (last day of treatment). Follow up phone surveys were conducted from 12-20 months post treatment (N= 27). Patients reported severity of cravings (1-5) and number of relapse episodes at the present time.
NAD+ is an effective detox treatment for alcohol and opiate addicts as evidenced by a significant reduction in craving ratings.NAD+ was effective in reducing and maintaining the number of relapse episodes, as well as severity of drug cravings.NAD+ shows potential as a long-term therapy in maintaining sobriety through minimizing drug cravings and preventing relapse.
* S. L. BROOM1, R. MESTAYER2, E. STULLER3, D. COOK4, J. CARSON2, K. SIMONE2, P. NORRIS2, P. HOTARD21 Dept Psychol, William Carey Univ., Hattiesburg, MS; 2Springfield Wellness Center, Springfield, LA; 3Stullerresettings, LLC; 4ABAM.SoberMD,LLC
Acknowledgements: Thank you to Springfield Wellness Center for providing patient data. Thank you to William Carey University for providing a Professional Development Grant in support of this project.
Words of Satisfaction
When they put the IV in me, it was such an incredible state of wellbeing but with energy. In my adult life, I have never felt like that on my own. And then, Paula, Dr. Mestayer, and the nurses would say, "How is the craving?" I said, "I haven't had one inkling of a craving whatsoever." It vanished in 20 minutes of the first IV. So I'm telling you that it worked immediately!
Family Member of Former Patient
The first two days were long but positive. The third day, he was like "I don't want pills anymore. I have no desire." And then day four, I could see his personality coming back. He's positive. He's himself. He's back. It's just amazing. Even more focused than before. More positive vibes. Just the energy is amazing. It works!
Day two, no more cravings. I could feel my attitude changing. I could feel myself looking towards the future: what I was going to do to resolve everything that I've been going through with relationships. Day three, the light came on and everything became so clear. Day four, I felt like I could really start reading. I started feeling like I could start focusing, again. Day 5, by that point, I felt like my spirit was new. Everything was new. From there, everything just went up!
I woke up the fourth morning, and everything was brighter. I had all my energy back. The biggest part with me is I don't have cravings anymore. It's more of a PTSD thing. One thing I had for seven years was nightmares every night. And now, after my third or fourth day treatment, my nightmares are gone. I come and get my boosters when I start losing sleep, and I'll be good for 28-30 days and start all over. It's been a lifesaver for me.
About 11 years ago, I was diagnosed with Parkinson's Disease. I met with several doctors, and they all said the same thing that it was irreversible and very very unsuccessful in treatment. It was being treated by a Physician, and he prescribed a whole bunch of medicine with little to no effects. I had tremors constantly. I tripped - unsteady on my feet. I couldn't eat with a fork; I had to eat with a spoon. I always saw images in my peripheral vision. I didn't get much sleep. So, I just about gave up. I met with Dr. Mestayer. He took down a medical history on me. I started receiving 1000 mg of NAD. Within an hour of the treatment, my tremors stopped almost immediately. I quit stumbling. I quit drooling at night. My peripheral vision was perfect; I saw no more images in my peripheral vision. It just makes you feel wonderful. You feel younger! It's remarkable.